Nurse practitioner salary in Missouri
Missouri nurse practitioners earn a median of $129,930 a year ($62.47 an hour), according to BLS data for May 2025. That is 2% below the national median of $132,300, and ranks 35th of 51 states.
Median, Missouri
$129,930
Mean $130,970
Middle half earns
$119,910 to $144,640
US: $117,990 to $156,700
Employed in Missouri
7,710
1.26x the national concentration
Where Missouri sits in the range
Missouri
Statewide
United States
National
St. Louis
Metro area
Kansas
Metro area
Springfield
Metro area
Columbia
Metro area
Nurse practitioner pay by percentile
Ten percent of Missouri nurse practitioners earned less than $100,650 and ten percent earned more than $162,060, a spread of $61,410. Where you land depends mostly on specialty, setting, experience and how the productivity pay is built, which is why two offers in the same city can be far apart.
| Percentile | Missouri | United States | Difference |
|---|---|---|---|
| 10th | $100,650 | $101,340 | -0.7% |
| 25th | $119,910 | $117,990 | +1.6% |
| Median | $129,930 | $132,300 | -1.8% |
| 75th | $144,640 | $156,700 | -7.7% |
| 90th | $162,060 | $174,420 | -7.1% |
Nurse practitioner pay by metro area
BLS published NP pay for 8 metro areas that include part of Missouri. St. Louis, MO-IL has the highest median at $131,580. Metro estimates rest on smaller samples than the statewide figure, so treat a low-precision row as a direction, not a number.
| Metro area | Employed | Median | Middle half |
|---|---|---|---|
| St. Louis, MO-IL | 3,430 | $131,580 | $127,460 to $154,500 |
| Kansas City, MO-KS | 2,730 | $130,760 | $120,120 to $144,550 |
| Springfield, MO | 660 | $125,630 | $108,590 to $130,850 |
| Columbia, MO | 330 | $128,930 | $109,070 to $130,920 |
| Joplin, MO-KS | 230 | $126,640 | $123,800 to $138,730 |
| Cape Girardeau, MO-IL | 200 | $130,000 | $119,500 to $139,690 |
| St. Joseph, MO-KS | 140 | $128,710 | $123,080 to $153,380 |
| Jefferson City, MO | 130 | $128,710 | $105,920 to $133,920 |
How NP pay compares with other clinicians in Missouri
| Occupation | Missouri | United States |
|---|---|---|
| Nurse practitioner | $129,930 | $132,300 |
| Physician assistant | $135,130 | $135,880 |
| Nurse anesthetist (CRNA) | $242,630 | $236,590 |
| Registered nurse | $81,780 | $97,550 |
The Missouri NP workforce
BLS counts 7,710 nurse practitioners on Missouri payrolls, or 2.63 for every 1,000 jobs in the state, more concentrated than in the country as a whole. The federal NPI registry, which also counts self-employed and part-time clinicians, lists 10,180 nurse practitioners with a Missouri practice address, and 498 new NP NPIs there in the past twelve months.
Using these numbers when you negotiate
A state median is a reference point, not a target. If an offer comes in under $119,910, it sits in the bottom quarter of what Missouri nurse practitioners earn, and you should know why before you sign: a new-grad rate, a light schedule, or a base kept low because a productivity bonus is supposed to make up the difference. If it is above $144,640, ask what is expected in return, such as call, volume targets or a longer non-compete.
Compare the whole package, not the base: how the bonus is calculated, call pay, CME, PTO and who pays malpractice tail coverage. The negotiation guide and the contract checklist walk through each term.
Questions about NP pay in Missouri
How much does a NP make in Missouri?
The median annual wage for nurse practitioners in Missouri was $129,930 in May 2025, and the mean was $130,970, per the BLS. The middle half earned between $119,910 and $144,640.
What is the hourly rate for nurse practitioners in Missouri?
The median hourly wage was $62.47 and the mean was $62.97. BLS computes hourly figures from annual pay assuming a full-time year, so per-shift or per-diem rates can differ.
Where do NPs earn the most in Missouri?
Among Missouri metro areas with published data, St. Louis, MO-IL had the highest median at $131,580, and Springfield, MO the lowest at $125,630.
How does Missouri rank for NP pay?
Missouri ranks 35th of 51 states (including DC) by median NP pay, 2% below the national median of $132,300. Pay is only half the picture: compare it with what housing and taxes cost where you would live.
How many nurse practitioners work in Missouri?
BLS estimated 7,710 nurse practitioners employed in Missouri in May 2025. The federal NPI registry lists 10,180 with a Missouri practice address.
Source: U.S. Bureau of Labor Statistics, Occupational Employment and Wage Statistics (OEWS), May 2025 (bls.gov/oes), SOC 29-1171, all industries and ownerships. NPI counts: NPPES monthly file, August 2026 (CMS, public domain). BLS wages are straight-time pay: they include production bonuses but leave out overtime, shift differentials, non-production bonuses and benefits, and they exclude the self-employed.
Have an offer on the table?
Book a free intro call with Max. Tell him what you are weighing, and he will tell you whether coaching would help, or whether you just need a few answers.